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Diagnostic value of cell free fetal DNA for detection of fetal abnormalities
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| Sedigheh Sharifzadeh1, Zeynab Keshavarz2 |
1- Diagnostic laboratry science and technology research center,School Of Paramedical Sciences,Shiraz University Of Medical Sciences
2- School Of Medical Sciences,Shiraz University Of Medical Sciences |
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Abstract: (6288 Views) |
| This review describes different characteristic of cell free fetal DNA including the origin, size and percentage of cell free fetal DNA compared to cell free maternal DNA. The small percentage of cell free fetal DNA in maternal plasma is the most important challenge for the routine usage of fetal DNA in clinic. After the discovery of cell-free fetal DNA in maternal blood during pregnancy, researchers tried to develop more reliable extraction and detection methods and now there are a promising view employing cell free fetal DNA for the non-invasive prenatal diagnosis. |
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| Keywords: Non- invasive prenatal diagnosis, cffDNA, Maternal plasma |
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Full-Text [PDF 406 kb]
(5431 Downloads)
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Type of Study: Applicable |
Subject:
ایمنی شناسی (ایمونولوژی)
Received: 2015/10/4 | Accepted: 2015/10/4 | Published: 2015/10/4
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