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:: year 9, Issue 38 (3-2018) ::
3 2018, 9(38): 62-72 Back to browse issues page
Circadian clock in human and its effects on human genetic diseases
Samira Shabani Ms 1, Sadegh Valian Dr2
1- (MSc) Division of genetics, Department of Biology Faculty of Science, University of Isfahan, Isfahan, IR Iran
2- (PhD)Division of genetics, Department of Biology Faculty of Science, University of Isfahan, Isfahan, IR Iran
Abstract:   (637 Views)
Nobel Prize of medicine and physiology has granted to detector scientists of biological clock in 2017 which shows the importance of this phenomenon in life of creations. All organisms like humans possess an inner biological clock which helps them in adaptation with regular rhythms of day and night. Circadian rhythms of human are inner rhythms with stretch about 24 hours which are directed by environment signs like lightness/darkness cycle. The main part of clock harmony of body circadian is located in suprachiasmatic nucleus (SCN) in hypothalamus. Circadian clock system adjust many biological activities of humans. Recent advanced research, has drastically showed the role of genetic factors in circadian rhythmic system. The relationship between disorder in circadian rhythm and its genes has been reported with a many human diseases. Here, a brief explanation of relationship of this system with sleep disorder diseases, autism spectrum disorder (ASD) and different kinds of cancers in human is represented.
Keywords: Circadian rhythms, Circadian clock, Sleep disorder, Cancer
Full-Text [PDF 487 kb]   (492 Downloads)    
Type of Study: Review | Subject: ژنتیک
Received: 2018/03/12 | Accepted: 2018/03/12 | Published: 2018/03/12
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Shabani S, Valian S. Circadian clock in human and its effects on human genetic diseases. 3. 2018; 9 (38) :62-72
URL: http://labdiagnosis.ir/article-1-263-en.html


year 9, Issue 38 (3-2018) Back to browse issues page
Laboratory & Diagnosis
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