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:: year 12, Issue 48 (8-2020) ::
3 2020, 12(48): 46-54 Back to browse issues page
Klotho Protein,A Biomarker for AKI
Fariba Nabatchian Dr 1, Fariba Nabatchian Dr1, Negin Davoudi Dr2
1- Faculty of Allied Medical Sciences, Tehran University of Medical Sciences
2- Tehran University of Medical Sciences
Abstract:   (259 Views)
Klotho is an anti-aging single-pass membrane protein that is mainly produced in the kidney. The level of soluble klotho decreases with age and the klotho gene is associated with an increased risk of age-related diseases, such as diabetes, skin atrophy, chronic kidney disease, ataxia and cancer.
The klotho gene is composed of five exons and encodes a membrane glycoprotein located in the plasma membrane.
The 3 forms of klotho protein have a specific function:
1-klotho forms a complex membrane protein with fibroblast growth factor receptors (FGFR) and acts as a binding cofactor for FGF23, which is involved in the regulation of aging and the development of chronic diseases through the regulation of ionized phosphorus and vitamin D metabolism.
2- Secretory klotho as a humoral agent has pleiotropic activity which includes regulation of oxidative stress, growth factor signaling and ion homeostasis. Secretory klotho also plays a role in organ protection.
3- The intracellular form of Klotho suppresses inflammation caused by cellular aging and mineral metabolism.
Keywords: Acute Kidney Injury, Chronic Kidney Injury, Klotho Protein
Full-Text [PDF 634 kb]   (135 Downloads)    
Type of Study: Review | Subject: بیوشیمی
Received: 2020/09/16 | Accepted: 2020/09/16 | Published: 2020/09/16
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Nabatchian F, Nabatchian F, Davoudi N. Klotho Protein,A Biomarker for AKI. 3. 2020; 12 (48) :46-54
URL: http://labdiagnosis.ir/article-1-407-en.html


year 12, Issue 48 (8-2020) Back to browse issues page
Laboratory & Diagnosis
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