Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. The most common hematologic finding is anemia, leukopenia, thrombocytopenia and secondary antiphospholipid syndrome with recurrent abortion and thrombosis. The autoimmune fibrosis of bone marrow is another manifestation of autoimmune disease especially SLE, that must be correctly differentiated from primary myelofibrosis.