:: year 13, Issue 54 (3-2022) ::
3 2022, 13(54): 17-32 Back to browse issues page
The Effect of Preanalytical, Analytical, and Postanalytical Variables on D-dimer Measurement
Shahrouz Hemmati 1, Mahnaz Aleyasin2
1- Iranian Association of Clinical Laboratory Doctors, Founder and Technical Director of Medical Diagnostic Laboratory
2- Founder and Technical Director of Medical Diagnostic Laboratory
Abstract:   (6301 Views)
D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of activation of coagulation and fibrinolysis, and it is routinely used for ruling out venous thromboembolism (VTE). D-dimer is increasingly used to assess the risk of VTE recurrence and to help define the uoptimal duration of anticoagulation treatment in patients with VTE, for diagnosing disseminated intravascular coagulation, and for screening medical patients at increased risk of VTE. This review is aimed at (1) revising the definition of D-dimer; (2) discussing preanalytical variables affecting the measure- ment of D-dimer; (3) reviewing and comparing assay performance and some postanalytical varia- bles (e.g. different units and age-adjusted cutoffs); and (4) discussing the use of D-dimer measurement across different clinical settings.
Keywords: D-Dimer, VTE, Pre analytical variables, analytical, post analytical, DDU, FEU, Standardization, Harmonization
Full-Text [PDF 645 kb]   (1031 Downloads)    
Type of Study: Review | Subject: علوم آزمایشگاهی
Received: 2022/03/9 | Accepted: 2022/03/9 | Published: 2022/03/9

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year 13, Issue 54 (3-2022) Back to browse issues page