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3 2021, 13(53): 51-60 Back to browse issues page
The importance of epigenetic modifications in cancer progression
Mahdieh Yavari 1, Sadegh Valian Borujeni1
1- Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Isfahan, IR Iran
Abstract:   (777 Views)
Epigenetics are dynamic and inherited changes in the genome that occur independently of DNA sequencing. This phenomenon requires coherent interaction with various enzymes and other molecular components. Abnormal epigenetic changes can lead to the onset of improper gene expression and the promotion of tumorigenesis. Because epigenetic changes are prone to external and reversible factors, they are becoming promising targets in the treatment of multiple cancers. Recently, various epigenetic drugs have been developed and are involved in clinical use. The use of epigenetic drugs alone or in combination with chemotherapy or immunotherapy has shown convincing results, including increased antitumor effects, overcoming drug resistance, and activation of the host immune response.
Keywords: Epigenetics, Cancer, Chemotherapy, Epigenetic drugs
Full-Text [PDF 306 kb]   (233 Downloads)    
Type of Study: Review | Subject: ژنتیک
Received: 2021/12/20 | Accepted: 2021/12/21 | Published: 2021/12/21
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Yavari M, Valian Borujeni S. The importance of epigenetic modifications in cancer progression. 3. 2021; 13 (53) :51-60
URL: http://labdiagnosis.ir/article-1-474-en.html

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year 13, Issue 53 (12-2021) Back to browse issues page
Laboratory & Diagnosis
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