1- Faculty of Allied Medical Sciences, Medical Sciences University of Tehran, Iran 2- of Tehran,Tehran, Iran
Abstract: (6996 Views)
Background: ER-alpha and ER-beta genes have been proven to play a significant role in breast cancer. Epidemiologic studies have revealed that age-incidence patterns of breast cancer in Middle East differ from those in the Western countries.
Methods: Two selected coding regions in the ER-β gene (exons 3 and 7) were scanned in Iranian women with breast cancer (150) and in healthy individuals (147). PCR single-strand conformation polymorphism was performed.
Results: A site of silent single nucleotide polymorphism was found only on exon 7. The SNP was found only in breast cancer patients (5.7%) (χ2 = 17.122, P = 0.01). Codon 392 (C1176G) of allele 1 was found to have direct association with the occurrence of lymph node metastasis.
Conclusion: Our data suggest that ER-β polymorphism in exon 7 codon 392 (C1176G) is correlated with various aspects of breast cancer and lymph node metastasis in our group of patients.
Abbasi S, Kalbasi S. The novel rs1256054 Polymorphism in Estrogen receptor beta gene and breast cancer risk. 3 2016; 8 (32) :36-47 URL: http://labdiagnosis.ir/article-1-173-en.html