Ewingella americana are Gram-negative, oxidase-negative, catalase-positive, lactose-fermenting, and bacterium that is as a new genus and species in the family Enterobacteriaceae. Ewingella americana is very public in some potatoes and mushrooms, in which it can cause a browning disorder called internal stipe necrosis. However, in humans, the discovery of Ewingella americana in the tissues and bodily fluids of patients with infectious diseases is very unusual. The true role of this agent has not   been exactly defined. In particular, it is not recognized whether Ewingella americana is a exact pathogen or purely an opportunistic infectious agent. However, the most of the cases have been described in at patients at risk. This paper presents Ewingella americana may be as a human disease.