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Methods for assessing insulin sensitivity and resistance
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Mohammad Ali Takhshid1   , Mohammad Ghasemi1 |
| 1- Shiraz University of Medical Sciences |
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Abstract: (14149 Views) |
| Insulin resistance (IR) is typically defined as decreased sensitivity or responsiveness to metabolic actions of insulin. IR is a central feature of metabolic syndrome and strongly associated with an increased risk of cardiovascular disease and diabetes. Therefore, quantifying of IR is of great importance for epidemiological, clinical and basic studies. There are many methods available for estimation of IR which range from complex techniques down to simple indices. The gold standard method for the determination of IR is the euglycaemic hyperinsulinaemic clamp. The clamp technique is both expensive and complex to undertake and has prompted the use of simple methods, notably the homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI) and biological markers. These indices are useful for use in large population studies where a relatively simple, inexpensive assessment is necessary. However, these tests all suffer from important limitations, including poor precision. |
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| Keywords: Laboratory procedures, Susceptibility and Resistance, Insulin |
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Full-Text [PDF 588 kb]
(29595 Downloads)
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Type of Study: Review |
Subject:
Special
Received: 2014/06/23 | Accepted: 2014/06/23 | Published: 2014/06/23
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