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A review on the latest clinical and laboratory criteria for clinical diagnosis of Rheumatoid Arthritis
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Sedigheh Sharifzadeh1   , Fatemeh Nasri1 |
| 1- Shiraz University of Medical Sciences, School of Paramedical Sciences |
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Abstract: (1067 Views) |
Rheumatoid arthritis (RA) is a multi-faceted inflammatory disease which affects joints and other organs. The pathophysiology of RA is not completely clear and no gold standard test exists to confirm disease diagnosis. Regarding the presence of non-specific clinical manifestations in the course of the disease, it is important to be able to identify the RA phenotype at an early stage of the disease development to delay or prevent the disease from becoming chronic and reduce the possibility of erosive changes to the joints. There are some laboratory tests including rheumatoid factor (RF), anti- cyclic citrullinated peptides (anti-CCP), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) helping the RA diagnosis along with joints involvement. It is aimed to present the last classification criteria to diagnose RA disease in patients at risk of developing persistent and erosive arthritis. These criteria for RA have been presented by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) in 2010.
Along with the above mentioned tests, measurement of 14-3-3ƞ protein complementary to RF and anti –CCP is recommended by some researchers for increasing sensitivity of RA diagnosis.
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Article number: 1 |
| Keywords: RA, ACR/ EULAR, ACPA, RF 14-3-3ƞ, Arthritis |
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Full-Text [PDF 459 kb]
(1295 Downloads)
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Type of Study: Review |
Subject:
ایمنی شناسی (ایمونولوژی)
Received: 2023/06/27 | Accepted: 2023/06/27 | Published: 2023/06/27
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