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Explanation of Conflict of Interest in the Field of Health with Laboratory System Approach: A Comprehensive Reviews Study
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Hossien Dargahi   1, Mehdi Kooshkbaghi2 |
1- School of Public Health, Health Information Management Research Center, Tehran University of Medical Sciences
2- Yas Hospital, Tehran University of Medical Sciences |
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Abstract: (479 Views) |
Trichophyton (T.) indotineae is a newly identified dermatophyte species that has been found in a near-epidemic form on the Indian subcontinent. There is evidence of its spread from the Indian subcontinent to a number of countries worldwide. The incriminated fungus is predominantly transmitted from person to person and often leads to refractory dermatophytosis. The causative dermatophyte has replaced the anthropophilic Trichophyton (T.) rubrum, the erstwhile predominant dermatophyte not only responsible for tinea pedis and onychomycosis, but also for dermatophytosis involving the whole body, worldwide—including India over the past few decades.
The fungus is identical to genotype VIII within the Trichophyton mentagrophytes/Trichophyton interdigitale species complex, which was described in 2019 by sequencing the Internal Transcribed Spacer (ITS) region of ribosomal DNA of the dermatophyte. More than 10 ITS genotypes of T. interdigitale and T. mentagrophytes can now be identified. T. indotineae causes inflammatory and itchy, often widespread, dermatophytosis affecting the groins, gluteal region, trunk, and face. Patients of all ages and genders are affected. The new species has largely displaced other previously prevalent dermatophytes on the Indian subcontinent. T. indotineae has become a problematic dermatophyte due to its predominantly in vitro genetic resistance to terbinafine owing to point mutations of the squalene epoxidase gene. It also displays in vivo resistance to terbinafine. The most efficacious drug currently available for this terbinafine-resistant dermatophytoses, based on sound evidence, is itraconazole.
As a result of globalization, this new emerging pathogen has been isolated in many countries outside Asia. Infections caused by the predominantly terbinafine-resistant dermatophytes—most prominently T. indotineae—are now found worldwide. T. indotineae appears to be spreading towards Europe, with notable presence in countries including United Arab Emirates, Oman, Bahrain, and Iran. Within Europe, the majority of non-Indian patients with tinea caused by this species have been reported in Germany . Furthermore, dermatophytoses due to T. indotineae has been described in France, Belgium, Switzerland, Greece, Denmark, China, Australia, Canada, and recently, in Vietnam.
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| Keywords: Conflict of Interest, Conflict of Interest Management, Clarity, Health Care and Services, Laboratory System |
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Full-Text [PDF 643 kb]
(338 Downloads)
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Type of Study: Review |
Subject:
دکترای مدیریت
Received: 2023/12/23 | Accepted: 2023/12/23 | Published: 2023/12/23
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