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Examining the HPV virus and taking a look at the new findings
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Daryoush Farhud1   , Fereshteh Khalilzadeh2 , Fatemeh Bitiyam2 , Parisa Verjavand2 |
1- Tehran University of Medical Sciences, Department of Basic Sciences/Ethics, Iran Academy of Medical Sciences, Aging Health Research Center, Genetics Clinic
2- genetics clinic |
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Abstract: (1269 Views) |
Human Papilloma Virus (PVs) induce warts on the skin and internal squamous mucosae, human papillomavirus can cause infection in actively dividing cells and requires host cells to replicate its genome. By entering the nucleus of the host cell, this virus transcribes and reproduces its genome. Only one strand of double-stranded DNA is used as a template for transcription and contains three genomic regions and about ten open reading frames (ORFs) encoded in the HPV genome. These frames consist of three functional regions: early region (E), late region (L) and non-coding or long control region (LCR). E region genes encode E1-E7 proteins that are essential for virus replication and play a role in virus pathogenesis. This virus may have specific clinical manifestations and although there are no definitive methods for the complete treatment of HPV infection. However, it can help manage the symptoms and health problems associated with HPV.
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| Keywords: Human Papilloma Virus, MACROD2, Epigenetics, Life cycle |
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Full-Text [PDF 928 kb]
(1515 Downloads)
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Type of Study: Review |
Subject:
ژنتیک
Received: 2023/12/23 | Accepted: 2023/12/23 | Published: 2023/12/23
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