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Kidney injury molecule-1 (KIM-1) a potential biomarker for early detection of AKI in neonates
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Fariba Nabatchian1   , Parmis Zand2 , Asal Taraghikhah2 , Toranj Sharifpour2 |
1- Department of Laboratory Sciences, Faculty of Paramedical Sciences, Tehran University of Medical Sciences
2- Faculty of Paramedical Sciences, Tehran University of Medical Sciences |
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Abstract: (556 Views) |
Background: Acute kidney injury (AKI) is a serious condition in critically ill newborns, marked by a sudden decline in kidney function. Traditionally, it is diagnosed using serum creatinine (Scr) levels, but Scr is not sensitive enough for early detection. This highlights the urgent need for more reliable biomarkers. This study explores kidney injury molecule-1 (KIM-1) as a potential early indicator of AKI in neonates receiving intensive care.
Method: This systematic review and meta-analysis adhered to PRISMA and Cochrane guidelines. A systematic search was conducted in databases such as PubMed, Scopus, and Web of Science, along with Google Scholar, using keywords and MeSH terms related to “KIM-1,” “Neonates,” and “AKI.” Two independent investigators performed searches and data extraction, resolving conflicts with a third author. The inclusion criteria focused on observational studies evaluating KIM-1 for AKI diagnosis in critically ill neonates, while exclusions encompassed reviews, animal studies, conference papers, book chapters, letters, trials, studies lacking a control group, and adult studies. Study quality was appraised using the Newcastle-Ottawa Scale, and heterogeneity was determined via I² statistics. Findings were reported as weighted mean differences (WMDs) and pooled area under the curve (AUC) with 95% confidence intervals (CI). Statistical analyses were performed using Stata 14.2.
Results: Out of 201 studies, 186 were excluded (114 duplicates, 72 irrelevant). In the end, 14 studies (10 case-control and 4 cohort studies) met the criteria for inclusion. The total sample consisted of 675 critically ill neonates, of whom 283 (42%) had AKI and 392 (58%) were in the control group. KIM-1 levels were significantly higher in neonates with AKI compared to those without (WMD = 0.91; 95% CI = 0.05-1.77; I² = 95.7%; Z = 2.07; P = 0.038). The pooled AUC was 0.72 (95% CI = 0.64-0.80; I² = 0%), indicating a moderate ability of KIM-1 to distinguish between AKI and non-AKI cases.
Conclusion: These findings suggest that KIM-1 could be a promising biomarker for the early detection of AKI in critically ill neonates, offering a potential improvement over traditional diagnostic methods. |
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| Keywords: KIM-1, neonate, AKI, critically ill |
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Full-Text [PDF 1070 kb]
(209 Downloads)
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Type of Study: Review |
Subject:
بیوشیمی
Received: 2025/03/11 | Accepted: 2025/03/11 | Published: 2025/03/11
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