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The importance of epigenetics in the breast cancer diagnosis
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Sadegh Vallian Borujeni1   , Zeynab Mashayekh1 |
| 1- Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Biotechnology, University of Isfahan, Isfahan, Iran |
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Abstract: (6 Views) |
Breast cancer is one of the most common cancers among women, especially young women. Delayed onset of symptoms and late diagnosis, limited treatment options, disease recurrence, and metastasis are among the factors that increase mortality of breast cancer. Breast cancer progression is a complex set of genetic and epigenetic alterations. Epigenetic modifications, including DNA methylation, protein phosphorylation, and non-coding RNA molecules (miRNAs, circRNAs, and lncRNAs), play a significant role in the gene expression regulation without changing the DNA sequence. On the other hand, epigenetic modifications are reversible that are influenced by internal and external stimuli that push the cell towards uncontrollable behavior. Recently, several studies have been conducted to investigate the role of epigenetics in relation to breast cancer. In this article, the aim is to discuss the importance and role of epigenetic factors as potential diagnostic, prognostic, and therapeutic biomarkers in breast cancer.
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| Keywords: Epigenetics, Breast Cancer, Biomarker, Methylation, miRNA |
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Full-Text [PDF 829 kb]
(3 Downloads)
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Type of Study: Review |
Subject:
ژنتیک
Received: 2026/09/28 | Accepted: 2026/09/29 | Published: 2026/09/29
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