The novel rs1256054 Polymorphism in Estrogen receptor beta gene and breast cancer risk
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Sakineh Abbasi 1, Samira Kalbasi2 |
1- Faculty of Allied Medical Sciences, Medical Sciences University of Tehran, Iran 2- of Tehran,Tehran, Iran |
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Abstract: (6564 Views) |
Background: ER-alpha and ER-beta genes have been proven to play a significant role in breast cancer. Epidemiologic studies have revealed that age-incidence patterns of breast cancer in Middle East differ from those in the Western countries.
Methods: Two selected coding regions in the ER-β gene (exons 3 and 7) were scanned in Iranian women with breast cancer (150) and in healthy individuals (147). PCR single-strand conformation polymorphism was performed.
Results: A site of silent single nucleotide polymorphism was found only on exon 7. The SNP was found only in breast cancer patients (5.7%) (χ2 = 17.122, P = 0.01). Codon 392 (C1176G) of allele 1 was found to have direct association with the occurrence of lymph node metastasis.
Conclusion: Our data suggest that ER-β polymorphism in exon 7 codon 392 (C1176G) is correlated with various aspects of breast cancer and lymph node metastasis in our group of patients. |
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Keywords: Breast cancer, estrogen receptor, LN metastases, polymorphism |
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Full-Text [PDF 491 kb]
(3366 Downloads)
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Type of Study: Review |
Subject:
ژنتیک Received: 2016/09/22 | Accepted: 2016/09/22 | Published: 2016/09/22
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