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:: year 9, Issue 37 (12-2017) ::
3 2017, 9(37): 7-13 Back to browse issues page
CRISPR/Cas9 technology and its application in treatment of genetic diseases
Sadegh Valian Borujeni Dr 1, Farzaneh Mohammadi Farasani Dr2
1- PhD and Professor of Human Molecular Genetics, Division of genetics Department of biology, Faculty of science, University of Isfahan, Isfahan, IR Iran
2- PhD in Molecular Genetics, Division of genetics Department of biology, Faculty of science, University of Isfahan, Isfahan, IR Iran
Abstract:   (1099 Views)
The development of recombinant DNA technology in the 1970s marked the beginning of a new era for biology. For the first time, molecular biologists gained the ability to manipulate DNA molecules, making it possible to develop novel medicine. Nowadays, the introduction of targeted genomic sequence changes into living cells and organisms has become a powerful tool for biological research and provided a potential avenue for therapy of genetic diseases. Of these new technologies, the most exciting is CRISPR/Cas9, a gene editing system adopted from bacterial immune system that is efficient, rapid, and easy-to-use. CRISPR/Cas9 technology allows targeted knock-in and knock-out and/or changes of any gene within the genome. In this study, this technology and its applications in treatment of genetic disease was discussed.
Keywords: Gene editing, CRISPR/Cas9, treatment of genetic diseases
Full-Text [PDF 464 kb]   (984 Downloads)    
Type of Study: Review | Subject: ژنتیک
Received: 2017/12/20 | Accepted: 2017/12/20 | Published: 2017/12/20
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Valian Borujeni S, Mohammadi Farasani F. CRISPR/Cas9 technology and its application in treatment of genetic diseases. 3. 2017; 9 (37) :7-13
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year 9, Issue 37 (12-2017) Back to browse issues page
Laboratory & Diagnosis
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