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3 2013, 5(21): 27-30 Back to browse issues page
Importance of Avidity IgG for differentiation of Acute Toxoplasma gondi infection
Mohammad Reza Bonyadi Dr 1, Shahindokht Pouzesh Ms2
1- Immunology research center, Department of Immunology, Tabriz University of Medical Sciences
2- Islamic Azad of University Tabriz
Abstract:   (8515 Views)

Objective: Toxoplasmosis has been well known as an important human infection to consider especially in pregnant women. Although many serologic methods are available, the diagnosis of early toxoplasmosis can be extremely difficult. The aim of this study is detecting Toxoplasma IgG antibodies developed at early stage of infection in pregnant women.

Method: 225 pregnant womens who were in 2-4 months of their pregnancy, enrolled in this study. They were categorized into three groups. Anti toxoplasma IgG , IgM and IgG Avidity were evaluated by ELISA method.

Results: Group A: 124 case (IgG+, IgM+) (55.1 percent), group B: 99 case (44percent)(IgG+,IgM-), and group C: 2 case (0.9 percent)( IgG -, IgM +). Fifty five percent of the pregnant women had positive IgG and IgM among whom 7.1 percent had low avidity that reveals the active infection in the pregnant women.

In the current study 44 percent of the pregnant women had positive IgG and negative IgM that all had high avidity which indicates that in our society the level of toxoplasma infection is high and women have contact with this parasite before pregnancy.

Conclusion: In this study the low avidity was 7.1 percent which shows that in different societies, the occurrence of toxoplasma infection is still a serious issue. Observation of 45.8 percent high avidity among group A suggests that either IgM has a high half-life or the false existence of IgM in Rheumatologic disorders makes it positive falsely. Therefore, avidity test has a high value and by a timely differential diagnosis of active toxoplasma infection, it would be cured.

Full-Text [PDF 247 kb]   (10244 Downloads)    
Type of Study: Research | Subject: Special
Received: 2014/01/18 | Accepted: 2014/01/18 | Published: 2014/01/18
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Bonyadi M R, Pouzesh S. Importance of Avidity IgG for differentiation of Acute Toxoplasma gondi infection. 3. 2013; 5 (21) :27-30
URL: http://labdiagnosis.ir/article-1-27-en.html

year 5, Issue 21 (11-2013) Back to browse issues page
Laboratory & Diagnosis
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