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:: year 10, Issue 41 (12-2018) ::
3 2018, 10(41): 56-61 Back to browse issues page
Proteins of Bartonella bacilliformis: Candidates for Vaccine Development
Reza Bohloli Khiavi Mr 1, Esmael Nourizadeh Mr2
1- Ardebil University of Medical Sciences, Meshkin Shahr Health and Treatment Center
2- Ardebil University of Medical Sciences, Meshkin Shahr City Health and Treatment Center
Abstract:   (371 Views)
Bartonella bacilliformis is the etiologic agent of Carrion’s disease or Oroya fever.B. bacilliformis infection represents an interesting model of human host specificity. The notable differences in clinical presentations of Carrion’s disease suggest complex adaptations ´ by the bacterium to the human host, with the overall objectives of persistence, maintenance of a reservoir state for vectorial transmission, and immune evasion. These events include a multitude of biochemical and genetic mechanisms involving both bacterial and host proteins. This review focuses on proteins involved in interactions between B. bacilliformis and the human host. Some of them (e.g., flagellin, Brps, IalB, FtsZ, Hbp/Pap31, and other outer membrane proteins) are potential protein antigen candidates for a synthetic vaccine.
 
Keywords: Bartonella bacilliformis, Oroya fever, antigen candidate proteins
Full-Text [PDF 313 kb]   (95 Downloads)    
Type of Study: Review | Subject: میکروب شناسی و باکتری شناسی
Received: 2018/12/20 | Accepted: 2018/12/20 | Published: 2018/12/20
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Bohloli Khiavi R, Nourizadeh E. Proteins of Bartonella bacilliformis: Candidates for Vaccine Development. 3. 2018; 10 (41) :56-61
URL: http://labdiagnosis.ir/article-1-311-en.html


year 10, Issue 41 (12-2018) Back to browse issues page
Laboratory & Diagnosis
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