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3 2019, 10(42): 58-60 Back to browse issues page
Coombs Test Requirements
Kamran Atarodi Dr
High Institute for Research and Education in Transfusion Medicine
Abstract:   (422 Views)
Many of the recent advances in modern blood transfusion are due to the development of an anti-globulin test or coombs test. Without this invention, the pathology of most hemolytic anemia remains undoubtedly unclear. We also witnessed at least the delayed hemolytic transfusion reactions. Despite the use of hemagglutination-enhancing agents such as polyethylene glycol, low ionic strength saline, albumin and various enzymes, some IgG antibodies are not able to produce hemagglutination. The anti-globulin reagent allows the detection of hemagglutination by creating a bridge between the pre-sensitized red blood cells with antibodies or complements. In this document, the implementation requirements of the coombs test and the quality control and validation of its results was discussed.
Keywords: Transfusion Medicine, Anti-globulin test, Hemolytic anemia, Delayed hemolytic transfusion reaction
Full-Text [PDF 389 kb]   (288 Downloads)    
Type of Study: Review | Subject: خون شناسی (هماتولوژی)
Received: 2019/03/10 | Accepted: 2019/03/10 | Published: 2019/03/10
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Atarodi K. Coombs Test Requirements. 3. 2019; 10 (42) :58-60
URL: http://labdiagnosis.ir/article-1-321-en.html

year 10, Issue 42 (3-2019) Back to browse issues page
Laboratory & Diagnosis
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