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Liquid Biopsy and its Applications
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Shahram Nemati   |
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Abstract: (283 Views) |
In recent years simultaneously with developing of technology it is now possible to precisely detect cancer cells or pieces of DNA called circulating tumor DNA, through a process termed as liquid biopsy, from biological fluids such as blood, urine, saliva and cerebrospinal fluid. With considering the limitation of this assay such as Non-informative result due to false negative tests using the liquid biopsy might become routine in clinical practice and lead to identification of actionable mutations and subsequent targeted therapy. Despite tissue biopsy is considered as the gold standard technique for determination of molecular signatures of cancer cells, it has some major issues. It provides just a molecular snapshot from the certain location of an individual tumor whereas the liquid biopsy provides a general picture of all mutations in the primary and metastatic tumors. Moreover the liquid biopsy is fast and the only method that can be used in the patients with inappropriate performance status, inaccessible tumor location and those having a poor quality of specimens obtained by tissue biopsy. In this review, we briefly describe liquid biopsy method and its applications in clinical practice.
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| Keywords: Liquid Biopsy, Circulating Tumor DNA, Actionable Mutations, Targeted Therapy |
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Full-Text [PDF 933 kb]
(189 Downloads)
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Type of Study: Review |
Subject:
ژنتیک
Received: 2024/09/23 | Accepted: 2024/09/24 | Published: 2024/09/24
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