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:: year 8, Issue 32 (9-2016) ::
3 2016, 8(32): 18-24 Back to browse issues page
Medical Importance of Dematiaceous Fungi (8): Keratiti
Mohammad Ghahri
Imam Hossein University, Tehran, Iran
Abstract:   (5727 Views)

Mycotic keratitis is a potentially sight-threatening fungal infection of the cornea. Fungi have been found responsible for about 6% to 53% of cases of ulcerative keratitis. More than 70 species have been reported to cause mycotic keratitis. Dematiaceous fungi follow Fusarium and Aspergillus species among the most common etiologic agents. Mycotic keratitis cases have been reported from a worldwide distribution but are more common in tropical and subtropical climates. Keratitis due to the more common dematiaceous pathogens is low grade and slowly progressive compared with that caused by more aggressive organisms. The mycotic keratitis ulcer is slowly progressive compared with that seen in bacterial keratitis and normally involves the central cornea. The base of the ulcer is normally dry, with a gray or witish base, and its edges are raised and thickened. Linear infiltrates with a feathery texture may radiate from the ulcer edges, giving rise to satellite lesions. Ring infiltrates and hypopyon can also be seen. A macroscopic brown pigmentation of the corneal infiltrate has been seen in cases due to dematiaceous fungi. It is difficult to clinically distinguish between bacterial and fungal keratitis. For this reason and because of the potential for development of sight-threatening complications such as endophthalmitis, early diagnosis under the guidance of an ophthalmologist and prompt institution of therapy is essential. The best diagnostic approach is to obtain scrapings from the base and edges of the ulcer using a spatula or surgical blade for direct microscopic examination and culture. If inadequate material is obtained, a corneal biopsy can be sentfor histopathology and culture. The most frequently implicated dematiaceous agents of keratitis include Curvularia species, Alternaria species, Bipolaris species, and Botryodiplodia theobromae.

Keywords: Dematiaceous fungi, Mycotic keratitis, keratomycosis, ulcerative keratitis
Full-Text [PDF 420 kb]   (5001 Downloads)    
Type of Study: Review | Subject: قارچ شناسی
Received: 2016/09/22 | Accepted: 2016/09/22 | Published: 2016/09/22
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Ghahri M. Medical Importance of Dematiaceous Fungi (8): Keratiti. 3 2016; 8 (32) :18-24
URL: http://labdiagnosis.ir/article-1-175-en.html


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year 8, Issue 32 (9-2016) Back to browse issues page
Laboratory and Diagnosis
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