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Hereditary Cancer Syndromes
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Mahta Mazaheri1   , Elaheh Ashegh Madineh2 , Mohammad Fasihi2 , Mahdieh Yavari3 |
1- Shahid Sadoughi University of Medical Sciences, Yazd; Mother and Newborn Health Research Center
2- Shahid Sadoughi University of Medical Sciences, Yazd
3- Mother and Newborn Health Research Center |
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Abstract: (30 Views) |
Hereditary Cancer Syndromes (HCSs) are groups of genetic disorders in which inherited mutations in specific genes increase the likelihood of developing various types of cancer. These syndromes are often identifiable through characteristic family patterns and early onset. In this article, the most important types of hereditary syndromes are reviewed, including Hereditary Renal Cancer Syndrome (HRCS), Hereditary Gastric Cancer (HGC), Hereditary Melanoma, and Hereditary Thyroid Cancer. The associated diagnostic and therapeutic strategies are also examined. The results of this review indicate that accurate and early identification of mutations related to familial cancers can be effective in prevention, screening, and therapy. Recent studies focus on the role of various tumor suppressor genes and their association with cancer signaling pathways. Moreover, existing drugs that target specific molecular pathways have generated new hope in the treatment of hereditary cancers. This research emphasizes the necessity of genetic counseling and precise screening for individuals with a family history, in order to facilitate earlier diagnosis and more effective preventive interventions.
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| Keywords: Hereditary Cancer Syndromes, Hereditary Gastric Cancer, Hereditary Renal Cancer, Hereditary Melanoma, Hereditary Thyroid Cancer |
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Full-Text [PDF 594 kb]
(18 Downloads)
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Type of Study: Review |
Subject:
ژنتیک
Received: 2025/09/23 | Accepted: 2025/09/25 | Published: 2025/09/25
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