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New Laboratory Biomarkers in Diagnosis of Sepsis
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Narges Asadi1   , Mehrdad Jamadi1 , Habib Zeyghami2 |
1- Department of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
2- School of Medicine, Zanjan University of Medical Sciences, Iran |
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Abstract: (25 Views) |
Sepsis is a life-threatening clinical syndrome in which an inappropriate immune system response to an infection can led to organ failure and ultimately death. Early diagnosis of sepsis can greatly increase a person's chances of treatment and survival. Therefore, in this review article, we aim to investigate sepsis biomarkers for faster and more accurate detection. According to studies conducted in the field of sepsis, older biomarkers for identifying sepsis, such as procalcitonin and CRP, have some limitations. But newer biomarkers, such as microRNAs, have been shown to perform better than older biomarkers. Some of these biomarkers go even further and can be used for prediction and prognosis of sepsis. Somehow, others can be used to monitor the effectiveness of treatment in an individual. Today's advances in technology have made it possible for us to easily measure these biomarkers. However, due to the complex pathophysiology of sepsis, despite these advances, there is still no standard method for accurately identifying sepsis as a reference method, and diagnoses are based on the simultaneous use of multiple biomarkers, and further studies are needed to find a comprehensive method. |
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| Keywords: Laboratory Diagnosis, Biomarker, Sepsis |
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Full-Text [PDF 576 kb]
(14 Downloads)
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Type of Study: Review |
Subject:
میکروب شناسی و باکتری شناسی
Received: 2025/09/23 | Accepted: 2025/09/25 | Published: 2025/09/25
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