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:: year 15, Issue 62 (2-2024) ::
3 2024, 15(62): 60-65 Back to browse issues page
- Discoveries related to nucleoside base modifications, an effective factor in the production of effective mRNA vaccines against COVID-19
Daryoush Farhoud 1, Fereshteh Khalilzadeh2
1- Tehran University of Medical Sciences, Genetics Clinic
2- genetics clinic
Abstract:   (737 Views)
The 2023 Nobel Prize in Medicine was awarded to Katalin Karikó and Drew Wiseman for the development of an mRNA-based COVID-19 vaccine. The two scientists began researching mRNA as a platform for protein replacement therapies in the early 1990s but ran into problems due to its inflammatory properties. Their breakthrough discovery in 2005 showed that replacing uridine with pseudouridine renders mRNA non-immunogenic. This paved the way for the development of mRNA-based vaccines at an unprecedented rate and saved countless lives during the COVID-19 pandemic. The purpose of this article is to express the mechanism of vaccines produced based on mRNA and to describe the related research.
 
Keywords: Nobel 2023, Covid-19, research, vaccine, nucleotide bases, mRNA
Full-Text [PDF 941 kb]   (375 Downloads)    
Type of Study: Review | Subject: ژنتیک
Received: 2024/03/11 | Accepted: 2024/03/11 | Published: 2024/03/11
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Farhoud D, Khalilzadeh F. - Discoveries related to nucleoside base modifications, an effective factor in the production of effective mRNA vaccines against COVID-19. 3 2024; 15 (62) :60-65
URL: http://labdiagnosis.ir/article-1-567-en.html


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year 15, Issue 62 (2-2024) Back to browse issues page
Laboratory and Diagnosis
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