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Pseudohyperkalemia: A Review of Pre-analytical and Analytical Errors in Potassium Measurement
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Mohammad Ali Takhshid   |
| Department of Clinical Laboratory Sciences, Paramedical school, Shiraz, Iran |
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Abstract: (13 Views) |
Potassium is an essential electrolyte required for maintaining electrical balance and proper cellular function in the body. Diagnosis of hyperkalemia is critical because it can lead to serious cardiac, muscular, and neurological complications. However, pseudohyperkalemia resulting from pre-analytical and analytical errors may lead to misinterpretation of laboratory results and, consequently, an incorrect diagnosis of hyperkalemia. In vitro hemolysis, delays in separating serum or plasma from blood cells, inappropriate temperature and storage conditions, contamination during sample blood collection, myeloproliferative disorders, mechanical leukocyte lysis in malignancies, familial pseudohyperkalemia, and measurement interferences are among the major causes of pseudohyperkalemia. This review aims to investigate potential sources of error and to provide a systematic approach for identifying and minimizing laboratory errors that lead to pseudohyperkalemia. |
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| Keywords: Potassium, Hyperkalemia, Pseudohyperkalemia |
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Full-Text [PDF 479 kb]
(14 Downloads)
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Type of Study: Review |
Subject:
بیوشیمی
Received: 2026/06/28 | Accepted: 2026/06/28 | Published: 2026/06/28
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