Today rapid and progressive improvements in clinical laboratory science are provided in terms of diagnostic tests technology. These changes call for educated experts with sufficient practical skills who can use new technologies and modern equipment. In other words, the employment of experienced and skilled laboratory technicians and technologists, as the main assets of each laboratory, is a competitive advantage in maintaining standards in laboratory work. In this respect, designing and implementing appropriate assessment methods for evaluating practical skills of the students especially in their internship course will ensure the achievement of the learning objectives. It is clear that routine and simple assessment methods are not able to show the practical abilities of learners. Therefore, introduction of standard methods for evaluation of their performance is a vital necessity. In this review, some of the standard assessments of laboratory skills are mentioned.